The revolutionary event in the treatment of erectile dysfunction was the appearance of Sildenafil Citrate in 1996, which became known under the name “Viagra”. This drug, is taken orally in the form of tablets, increases the effectiveness of treatment and enables general practitioners to help patients with ED.
The next approved for use of PDE5 inhibitor after sildenafil was “Cialis” (Tadalafil). Unlike sildenafil, this drug has a long half-life (17.5 h) and its pharmacokinetics do not dependent on food and alcohol intake. Thus, the duration of Cialis (36 h) allows you to calmly treat the so-called planning of sexual intercourse and preserve the spontaneity and romanticism in sexual relations.
“Levitra” (Vardenafil hydrochloride) is a new, highly effective and most potent PDE5 inhibitor. Vardenafil with respect to the effect on PDE5 is stronger than sildenafil by more than 10 times. Vardenafil has a smaller influence on spermatogenesis in comparison with sildenafil.